Abstract
Aim:
To determine if CXCL12 (rs1801157) and CXCR4 (rs2228014) polymorphisms are associated with hepatocellular carcinoma (HCC) susceptibility, and detect their expressions in peripheral blood.
Methods:
206 HCC patients, 252 chronic hepatitis B patients, 221 liver cirrhosis patients and 275 healthy volunteers were recruited. Genes CXCL12 and CXCR4 were amplified and genotyped. Their expression in peripheral blood were detected.
Results:
CXCL12 rs1801157 and CXCR4 rs2228014 polymorphisms were associated with increased susceptibility of HCC, and genotypes GA/AA and CT/TT may be risk factors of HCC (all p < 0.05). Expressions of CXCL12 and CXCR4 in peripheral blood from HCC patients increased significantly (p < 0.05).
Conclusion:
CXCL12 and CXCR4 polymorphisms may be risk factors for HCC, and they may be potential HCC markers.
Keywords:
CXCL12; CXCR4; hepatocellular carcinoma; single nucleotide polymorphism.
MeSH terms
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Adult
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Alleles
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Biomarkers, Tumor / blood
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Biomarkers, Tumor / genetics*
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Carcinoma, Hepatocellular / blood
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Carcinoma, Hepatocellular / epidemiology
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Carcinoma, Hepatocellular / genetics*
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Carcinoma, Hepatocellular / virology
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Case-Control Studies
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Chemokine CXCL12 / blood
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Chemokine CXCL12 / genetics*
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China / epidemiology
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Female
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Genetic Predisposition to Disease
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Genotype
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Hepatitis B virus / isolation & purification
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Hepatitis B, Chronic / blood
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Hepatitis B, Chronic / genetics
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Hepatitis B, Chronic / virology
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Humans
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Incidence
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Liver Cirrhosis / blood
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Liver Cirrhosis / genetics
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Liver Cirrhosis / virology
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Liver Neoplasms / blood
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Liver Neoplasms / epidemiology
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Liver Neoplasms / genetics*
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Liver Neoplasms / virology
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Male
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Middle Aged
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Polymorphism, Single Nucleotide
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Receptors, CXCR4 / blood
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Receptors, CXCR4 / genetics*
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Sequence Analysis, DNA
Substances
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Biomarkers, Tumor
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CXCL12 protein, human
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CXCR4 protein, human
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Chemokine CXCL12
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Receptors, CXCR4