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Nature. 1988 Dec 15;336(6200):646-51.

The role of the leucine zipper in the fos-jun interaction.

Author information

1
Department of Biochemistry, New York University Medical Center, New York 10016.

Abstract

Mutagenesis of the fos protein supports the hypothesis that a heptad repeat of leucine residues stabilizes the interaction between the fos and jun proteins. We show that the complex between fos and jun can bind to DNA more tightly than either protein alone and that basic residues adjacent to the leucine repeat of fos contribute to the DNA-binding potential of the complex.

PMID:
2974122
DOI:
10.1038/336646a0
[Indexed for MEDLINE]

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