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J Perinatol. 2018 May;38(5):526-529. doi: 10.1038/s41372-018-0101-3. Epub 2018 May 8.

Safety of fentanyl for peripherally inserted central catheter in non-intubated infants in the neonatal intensive care unit.

Author information

1
Neonatal Intensive Care unit, Shaare Zedek Medical Center, Jerusalem, 9103102, Israel. yairkasirer@yahoo.com.
2
Department of Paediatrics, Mount Sinai Hospital, Department of Paediatrics and Institute of Health Policy, Management and Evaluation, University of Toronto Rm 19-231N, 600 University Avenue, Toronto, ON, Canada.
3
Maternal-Infant Care Research Centre, Mount Sinai Hospital, 700 University Ave. Room 8-500, Toronto, ON, Canada.
4
Department of Neonatology, Schneider Children's Medical Center of Israel, 14 Kaplan St., Petach Tikva, 4920235, Israel.
5
Department of Neonatology, Hospital for Sick Children, 555 University Ave, Toronto, ON, Canada.
6
Leslie Dan Faculty of Pharmacy, 144 College Street, Toronto, ON, Canada.

Abstract

OBJECTIVE:

To evaluate the safety of fentanyl in non-intubated infants undergoing peripherally inserted central catheter (PICC) placement.

METHODS:

A retrospective chart review of PICC placements over a 3 years' period. We compared the 12h periods before and after fentanyl for clinically significant cardiorespiratory events (spells).

RESULTS:

Of the 998 neonates screened, 258 were eligible. The mean standard deviation gestational age was 34.1 (4.3) weeks and the median (inter-quartile range) postnatal age was 4 (7, 11) days. The mean (standard deviation) fentanyl dose was 0.6 (0.2) µg/kg. Respiratory depression occurred only in two infants (prevalence rate = 0.78%, 95% CI (0, 1.85)). No cases of hypotension or chest wall rigidity occurred. There was no evidence of an increase in the number of infants with spells or in the number of spells per infant (p = 0.34 and p = 0.06, respectively).

CONCLUSION:

Fentanyl appears to be associated with only a small risk of respiratory depression in non-intubated infants.

PMID:
29740192
DOI:
10.1038/s41372-018-0101-3
[Indexed for MEDLINE]

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