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Pathophysiology. 2018 Dec;25(4):293-297. doi: 10.1016/j.pathophys.2018.04.005. Epub 2018 Apr 27.

Mimosa pudica Protects the Testes Against Cadmium-Induced Inflammation and Oligospermia: Potential Benefits in Treatment of Heavy Metal Toxicity.

Author information

1
Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria. Electronic address: onyije.felix@mail.ndu.edu.ng.
2
Department of Medical Laboratory Science, Faculty of Science, Rivers State University, Nkpolu-Oroworukwo, Port Harcourt, Rivers State, Nigeria.
3
Department of Pharmacognosy and Herbal Medicine, Faculty of Pharmacy, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.
4
Department of Medical Laboratory Science, Faculty of Basic Medical Sciences, College of Health Sciences, Niger Delta University, Wilberforce Island, Bayelsa State, Nigeria.
5
Department of Pharmaceutical Health Outcomes & Policy, College of Pharmacy, University of Houston, Texas Medical Center, Houston, TX, USA.

Abstract

Cadmium is a known environmental and industrial pollutant with an enormous tissue disrupting potential. Mimosa pudica (M. pudica) is a creeping annual or perennial herb known to possess anti asthmatic, anti-epileptic, anti-tumour, anti-fertility, aphrodisiac, analgesic, anti-depressant, sedative, emetic properties and a strong radical scavenging activity. This research was aimed at investigating the ameliorative effects of M. pudica on cadmium-induced testicular damage in adult male Sprague Dawley rats. Twenty adult Sprague Dawley rats were employed in the study. They were divided into 4 groups (A-D) of 5 rats each, and toxicity was induced by administering 0.4 mg/ml cadmium chloride through drinking water to groups B-D for 21days. M. pudica extract was administered orally at 250 and 500 mg/kg to groups C and D. Animals in Groups C and D showed remarkable histological improvements in testicular tissue and markedly reduced damages when compared with group B.The active sperm motility of group B (6.00 ± 1.00%) was significantly (p = 0.0001) decreased compared to that of the groups A (15.00 ± 0.00%)) and C (13.00 ± 1.22%). Sperm count analysis of group B (1.36 ± 0.28 × 106/cc), C (4.18 ± 0.81 × 106/cc) and D (2.54 ± 1.13 × 106/cc) were significantly lower (p = <0.05) when compared with group A (12.78 ± 0.92 × 106/cc), respectively. Sperm morphology of group A (70.00 ± 3.16%), B (66.00 ± 2.50), C (74.00 ± 2.45%) and D (64.00 ± 2.45%) recorded no significant difference. This study demonstrates that M. pudica has potential protective and restorative properties on the histoarchitecture of the testes of cadmium-treated rats.

KEYWORDS:

Cadmium chloride; Mimosa pudica; Sperm count; Sperm morphology; Sperm motility

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