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Ann Nutr Metab. 2018;72(4):336-344. doi: 10.1159/000488994. Epub 2018 May 8.

Muscle Mass Depletion Associated with Poor Outcome of Sepsis in the Emergency Department.

Author information

1
Department of Emergency Medicine, College of Medicine, Hanyang University, Seoul, Republic of Korea.
2
Department of Emergency Medicine, Kyung Hee University School of Medicine, Kyung Hee University Hospital at Gangdong, Seoul, Republic of Korea.
3
Department of Emergency Medicine, University of Ulsan College of Medicine, Asan Medical Center, Seoul, Republic of Korea.

Abstract

BACKGROUND/AIMS:

Muscle mass depletion has been suggested to predict morbidity and mortality in various diseases. However, it is not well known whether muscle mass depletion is associated with poor outcome in sepsis. We hypothesized that muscle mass depletion is associated with poor outcome in sepsis.

METHODS:

Retrospective observational study was conducted in an emergency department during a 9-year period. Medical records of 627 patients with sepsis were reviewed. We divided the patients into 2 groups according to 28-day mortality and compared the presence of muscle mass depletion assessed by the cross-sectional area of the psoas muscle at the level of the third lumbar vertebra on abdomen CT scans. Univariate and multivariate logistic regression analyses were conducted to examine the association of scarcopenia on the outcome of sepsis.

RESULTS:

A total of 274 patients with sepsis were finally included in the study: 45 (16.4%) did not survive on 28 days and 77 patients (28.1%) were identified as having muscle mass depletion. The presence of muscle mass depletion was independently associated with 28-day mortality on multivariate logistic analysis (OR 2.79; 95% CI 1.35-5.74, p = 0.01).

CONCLUSIONS:

Muscle mass depletion evaluated by CT scan was associated with poor outcome of sepsis patients. Further studies on the appropriateness of specific treatment for muscle mass depletion with sepsis are needed.

KEYWORDS:

Emergency department; Muscle mass depletion; Outcome; Sepsis

PMID:
29739009
DOI:
10.1159/000488994

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