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Nutrients. 2018 May 8;10(5). pii: E580. doi: 10.3390/nu10050580.

Protective Effect of Glucosinolates Hydrolytic Products in Neurodegenerative Diseases (NDDs).

Author information

1
Department of Biochemistry, Kaduna State University, Main Campus, PMB 2339 Kaduna, Nigeria. biojafar@gmail.com.
2
UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. biojafar@gmail.com.
3
UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. ck_zimase89@yahoo.com.
4
UPM-MAKNA Cancer Research Laboratory, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. en_mo2008@yahoo.com.
5
Université d'Orléans et CNRS, ICOA, UMR 7311, BP 6759, F-45067 Orléans, France. Patrick.Rollin@univ-orleans.fr.
6
IRCCS Centro Neurolesi "Bonino-Pulejo", Via Provinciale Palermo, Contrada Casazza, 98124 Messina, Italy. emazzon.irccs@gmail.com.
7
Laboratory of Molecular Biomedicine, Institute of Bioscience, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. madfaizal@upm.edu.my.
8
Laboratory of Food Safety and Food Integrity, Institute of Tropical Agriculture and Food Security, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. madfaizal@upm.edu.my.
9
Department of Food Science, Faculty of Food Science and Technology, Universiti Putra Malaysia, 43400 UPM Serdang, Selangor, Malaysia. madfaizal@upm.edu.my.

Abstract

Crucifer vegetables, Brassicaceae and other species of the order Brassicales, e.g., Moringaceae that are commonly consumed as spice and food, have been reported to have potential benefits for the treatment and prevention of several health disorders. Though epidemiologically inconclusive, investigations have shown that consumption of those vegetables may result in reducing and preventing the risks associated with neurodegenerative disease development and may also exert other biological protections in humans. The neuroprotective effects of these vegetables have been ascribed to their secondary metabolites, glucosinolates (GLs), and their related hydrolytic products, isothiocyanates (ITCs) that are largely investigated for their various medicinal effects. Extensive pre-clinical studies have revealed more than a few molecular mechanisms of action elucidating multiple biological effects of GLs hydrolytic products. This review summarizes the most significant and up-to-date in vitro and in vivo neuroprotective actions of sulforaphane (SFN), moringin (MG), phenethyl isothiocyanate (PEITC), 6-(methylsulfinyl) hexyl isothiocyanate (6-MSITC) and erucin (ER) in neurodegenerative diseases.

KEYWORDS:

crucifer vegetables; glucosinolates; isothiocyanates; neurodegenerative diseases

PMID:
29738500
PMCID:
PMC5986460
DOI:
10.3390/nu10050580
[Indexed for MEDLINE]
Free PMC Article

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