Format

Send to

Choose Destination
J Med Virol. 2018 Sep;90(9):1444-1452. doi: 10.1002/jmv.25222. Epub 2018 May 25.

Molecular detection and phylogenetic analysis of human parechovirus in individuals with acute diarrhea and healthy controls in Guangzhou, China.

Author information

1
Guangdong Provincial Key Laboratory of Tropical Disease Research, Department of Epidemiology, School of Public Health, Southern Medical University, Guangzhou, China.
2
Department of Hospital Infection Management, The Third People's Hospital of Hainan Province, Sanya, China.
3
Public Health Emergency Preparedness and Response Division, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.
4
Department of Medical Laboratory, The Third Affiliated Hospital of Southern Medical University, Guangzhou, China.
5
Department of Public Health, Shunde District Center for Disease Prevention and Control, Foshan, China.
6
Department of Disease Prevention and Control, Songgang Health Inspection and Prevention Institute, Shenzhen, China.
7
Institute of Non-communicable Disease Control and Prevention, Guangdong Provincial Center for Disease Control and Prevention, Guangzhou, China.

Abstract

Human parechoviruses (HPeVs) are prevalent in young children; however, their effects are incompletely understood. We investigated the prevalence, genotype distribution, and phylogeny of HPeVs in individuals with diarrhea (n = 430) and healthy controls (n = 93) by the analysis of stool specimens collected from July 2013 to December 2014; 51 (11.86%) and 6 (6.45%) specimens were HPeV positive, respectively. HPeV1A occurred in 28 (6.51%) and 6 (6.45%) individuals with diarrhea and controls, respectively, whereas HPeV1B (3.95%), HPeV3 (0.23%), HPeV4 (0.70%), and HPeV14 (a rare genotype, 0.47%) were only detected in individuals with diarrhea. There was no significant difference in the rate of HPeV detection between the 2 groups; however, the mean age of HPeV infection was significantly lower in males. We conclude that HPeVs may be opportunistic pathogens associated with acute diarrhea. Immunocompromised individuals, such as children aged under 2 years and the elderly, could be vulnerable to HPeV infections.

KEYWORDS:

child; diarrhea; genotype; parechovirus; phylogeny; preschool; prevalence

PMID:
29738080
DOI:
10.1002/jmv.25222
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Wiley
Loading ...
Support Center