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Panminerva Med. 2018 Jun;60(2):65-69. doi: 10.23736/S0031-0808.18.03419-5.

Pycnogenol® supplementation improves the control of irritable bowel syndrome symptoms.

Author information

1
IRVINE3 Labs, Chieti-Pescara University, Chieti, Italy - cardres@abol.it.
2
International Agency for Pharma Standard Supplements (IAPPS), Chieti, Italy - cardres@abol.it.
3
IRVINE3 Labs, Chieti-Pescara University, Chieti, Italy.
4
International Agency for Pharma Standard Supplements (IAPPS), Chieti, Italy.

Abstract

BACKGROUND:

The aim of this registry was to evaluate the effects of Pycnogenol® on the main symptoms of irritable bowel syndrome (IBS) in otherwise healthy individuals.

METHODS:

This study included 77 healthy individuals with symptoms of IBS. The patients were divided into three groups: group 1 was treated with Buscopan (10 mg when needed), group 2 (Antispasmina col forte; 50 mg papaverine hydrochloride+10 mg belladonna extract when needed) and 3 (Pycnogenol® 150 mg/day) for 3 weeks.

RESULTS:

The number of painful attacks was comparable in all groups after four weeks. Mild pain on manual abdomen pressure was decreased in all groups, with the improvement in the Pycnogenol® group significantly more pronounced that in both control groups (P<0.05). Perceived abdominal bowel movements/distension were significantly relieved in group 2 (Antispasmina Col Forte) and 3 (Pycnogenol®) (P<0.05) in comparison with Buscopan (group 1).

CONCLUSIONS:

Pycnogenol® has shown a significant, protective and preventive activity on IBS symptoms, and thus it may represent a potential "soft" approach to IBS.

PMID:
29737150
DOI:
10.23736/S0031-0808.18.03419-5
[Indexed for MEDLINE]
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