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Med Microbiol Immunol. 2018 Aug;207(3-4):243-248. doi: 10.1007/s00430-018-0544-3. Epub 2018 May 8.

Serum cytokine responses in Rickettsia felis infected febrile children, Ghana.

Author information

1
Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany. rauch@bnitm.de.
2
Bernhard Nocht Institute for Tropical Medicine, Bernhard-Nocht-Str. 74, 20359, Hamburg, Germany.
3
Division of Tropical Medicine, 1st Department of Medicine, University Medical Center Hamburg Eppendorf, Hamburg, Germany.
4
German Center for Infection Research (DZIF), Partner Site Hamburg-Borstel-Lübeck, Brunswick, Germany.
5
Kumasi Centre for Collaborative Research in Tropical Medicine, Kwame Nkrumah University of Science and Technology, Kumasi, Ghana.
6
School of Public Health, KNUST, Kumasi, Ghana.

Abstract

The intracellular pathogen Rickettsia felis causes flea-borne spotted fever and is increasingly recognized as an emerging cause of febrile illness in Africa, where co-infection with Plasmodium falciparum is common. Rickettsiae invade endothelial cells. Little is known, however, about the early immune responses to infection. In this study, we characterize for the first time the cytokine profile in the acute phase of illness caused by R. felis infection, as well as in plasmodial co-infection, using serum from 23 febrile children < 15 years of age and 20 age-matched healthy controls from Ghana. Levels of IL-8 (interleukin-8), IP-10 (interferon-γ-induced protein-10), MCP-1 (monocyte chemotactic protein-1), MIP-1α (macrophage inflammatory protein-1α) and VEGF (vascular endothelial growth factor) were significantly elevated in R. felis mono-infection; however, IL-8 and VEGF elevation was not observed in plasmodial co-infections. These results have important implications in understanding the early immune responses to R. felis and suggest a complex interplay in co-infections.

KEYWORDS:

Cytokine; Flea-borne spotted fever; Rickettsia felis; Rickettsiosis

PMID:
29736763
PMCID:
PMC6096778
DOI:
10.1007/s00430-018-0544-3
[Indexed for MEDLINE]
Free PMC Article

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