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eNeurologicalSci. 2018 Jan 28;10:37-44. doi: 10.1016/j.ensci.2018.01.007. eCollection 2018 Mar.

A review on potential roles of vitamins in incidence, progression, and improvement of multiple sclerosis.

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School of Medicine, Iran University of Medical Sciences, Tehran, Iran.
Department of Biotechnology, College of Science, University of Tehran, Tehran, Iran.
Department of Biochemistry, School of Medicine, Iran University of Medical Sciences, Tehran, Iran.


Multiple Sclerosis (MS) is an inflammatory and neurodegenerative disease, with unknown etiology. Vitamins, as important micronutrients playing different roles in body, seem to be important in MS pathogenesis. In vitro, in vivo and human studies, supports the protective role of some vitamins in MS occurrence or progression. Current study reviews recent insights and reports about the importance of vitamins in MS incidence or progression. In accordance, the importance of all water and fat-soluble vitamins in MS pathogenesis based on observational studies in human population and their role in the function of immune system as well as possible therapeutic opportunities are discussed in depth throughout this review.


Experimental autoimmune encephalomyelitis; Folic acid; Multiple sclerosis; Vitamin A; Vitamin B 12; Vitamin D; Vitamin E; Vitamins

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