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Ann Hepatol. 2018 Apr 9;17(3):476-481. doi: 10.5604/01.3001.0011.7392.

Thrombosis of the Portal Venous System in Cirrhotic vs. Non-Cirrhotic Patients.

Author information

1
Liver Research Unit. Medica Sur Clinic & Foundation, Mexico City, Mexico.
2
Radiology Department. Medica Sur Clinic & Foundation, Mexico City, Mexico.
3
Division of Gastroenterology and Hepatology. University of Virginia Medical Center, Charlottesville, USA.
4
Public Health Department. Faculty of Medicine, National Autonomous University of Mexico, Mexico City, Mexico.
5
Department of Gastroenterology. General Hospital of Shenyang, Military Area Command, Shenyang, China.

Abstract

INTRODUCTION AND AIM:

Thrombosis is a vascular disorder of the liver often associated with significant morbidity and mortality. Cirrhosis is a predisposing factor for portal venous system thrombosis. The aim of this study is to determine differences between cirrhotics and non-cirrhotics that develop thrombosis in portal venous system and to evaluate if cirrhosis severity is related to the development of portal venous system thrombosis.

MATERIAL AND METHODS:

We studied patients diagnosed with portal venous system thrombosis using contrast-enhanced computed tomography scan and doppler ultrasound at Medica Sur Hospital from 2012 to 2017. They were categorized into two groups; cirrhotics and non-cirrhotics. We assessed the hepatic function by Child-Pugh score and model for end-stage liver disease.

RESULTS:

67 patients with portal venous system thrombosis (25 with non-cirrhotic liver and 42 with cirrhosis) were included. The mean age (± SD) was 65 ± 9.5 years in cirrhotic group and 57 ± 13.2 years (p = 0.009) in non-cirrhotic group. Comparing non-cirrhotics and cirrhotics, 8 non-cirrhotic patients showed evidence of extra-hepatic inflammatory conditions, while in the cirrhotic group no inflammatory conditions were found (p < 0.001). 27 (64.29%) cirrhotic patients had thrombosis in the portal vein, while only 9 cases (36%) were found in non-cirrhotics (p = 0.02).

CONCLUSIONS:

In cirrhotic patients, hepatocellular carcinoma and cirrhosis were the strongest risk factors to develop portal venous system thrombosis. In contrast, extrahepatic inflammatory conditions were main risk factors associated in non-cirrhotics. Moreover, the portal vein was the most frequent site of thrombosis in both groups.

KEYWORDS:

Cirrhosis. Portal vein. Thrombus. Predictive factor. Hepatocellular carcinoma.

PMID:
29735798
DOI:
10.5604/01.3001.0011.7392
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