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Antimicrob Agents Chemother. 2018 Jun 26;62(7). pii: e00077-18. doi: 10.1128/AAC.00077-18. Print 2018 Jul.

Natamycin and Azithromycin Are Synergistic In Vitro against Ocular Pathogenic Aspergillus flavus Species Complex and Fusarium solani Species Complex Isolates.

Author information

1
Henan Eye Hospital & Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan, China.
2
Department of Optometry, Zhengzhou Railway Vocational & Technical College, Zhengzhou, Henan, China.
3
Department of Ophthalmology, Zhengzhou Second Hospital, Zhengzhou, Henan, China.
4
Henan Eye Hospital & Henan Eye Institute, Department of Ophthalmology, Henan Provincial People's Hospital, Zhengzhou, Henan, China xuyan990301@foxmail.com.

Abstract

The interaction of natamycin-azithromycin combination against 60 ocular fungal isolates was tested in vitro The combination produced 100% synergistic interactions when natamycin was added to azithromycin 20, 40, and 50 μg/ml against Aspergillus flavus species complex (AFSC) isolates and to azithromycin 50 μg/ml against Fusarium solani species complex isolates. Addition of 50 μg/ml azithromycin enhanced natamycin's effect against AFSC isolates by reducing natamycin MIC90 from 64 to 0.031 μg/ml. No antagonism was observed.

KEYWORDS:

Aspergillus flavus; Fusarium solani; azithromycin; fungal keratitis; natamycin; synergistic activity

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