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Dent J (Basel). 2018 May 6;6(2). pii: E12. doi: 10.3390/dj6020012.

The Use of Tooth Particles as a Biomaterial in Post-Extraction Sockets. Experimental Study in Dogs.

Author information

1
Faculty of Health Sciences, Universidad Católica de Murcia (UCAM), Campus de los Jerónimos N° 135, Guadalupe, 30107 Murcia, Spain. jlcalvo@ucam.edu.
2
Faculty of Health Sciences, Universidad Católica de Murcia (UCAM), Campus de los Jerónimos N° 135, Guadalupe, 30107 Murcia, Spain. jemate@ucam.edu.
3
Faculty of Health Sciences, Universidad Católica de Murcia (UCAM), Campus de los Jerónimos N° 135, Guadalupe, 30107 Murcia, Spain. mlramos@ucam.edu.
4
Faculty of Health Sciences, Universidad Católica de Murcia (UCAM), Campus de los Jerónimos N° 135, Guadalupe, 30107 Murcia, Spain. cperezalbacete@ucam.edu.
5
Department of Epidemiology, Universidad Católica de Murcia (UCAM), 30107 Murcia, Spain. mpramirez@ucam.edu.
6
Faculty of Health Sciences, Department of Oral and Implant Dentistry Universidad Católica de Murcia (UCAM), 30107 Murcia, Spain. sergio.gehrke@hotmail.com.
7
Biotecnos Research Center-Tecnología e Ciencia Ltd., 11100 Montevideo, Uruguay. sergio.gehrke@hotmail.com.
8
Faculty of Dentistry, Department of Oral and Implant Dentistry, San Pablo University CEU, Group HM (Hospital Madrid), 28050 Madrid, Spain. clinferfun@yahoo.es.
9
Department of Periodontology, School of Dental Medicine, Stony Brook University, New York, 11794 NY, USA. Georgios.Romanos@stonybrookmedicine.edu.
10
Department of Prosthodontics and Digital Technology, School of Dental Medicine, Stony Brook University, New York, 11794 NY, USA. Rafael.Delgado-Ruiz@stonybrookmedicine.edu.

Abstract

Objectives: The objective of this study was to evaluate new bone formation derived from freshly crushed extracted teeth, grafted immediately in post-extraction sites in an animal model, compared with sites without graft filling, evaluated at 30 and 90 days. Material and Methods: The bilateral premolars P2, P3, P4 and the first mandibular molar were extracted atraumatically from six Beagle dogs. The clean, dry teeth were ground immediately using the Smart Dentin Grinder. The tooth particles obtained were subsequently sieved through a special sorting filter into two compartments; the upper container isolating particles over 1200 &mu;m, the lower container isolated particles over 300 &mu;m. The crushed teeth were grafted into the post-extraction sockets at P3, P4 and M1 (test group) (larger and smaller post-extraction alveoli), while P2 sites were left unfilled and acted as a control group. Tissue healing and bone formation were evaluated by histological and histomorphometric analysis after 30 and 90 days. Results: At 30 days, test site bone formation was greater in the test group than the control group (p < 0.05); less immature bone was observed in the test group (25.71%) than the control group (55.98%). At 90 days, significant differences in bone formation were found with more in the test group than the control group. No significant differences were found in new bone formation when comparing the small and large alveoli post-extraction sites. Conclusions: Tooth particles extracted from dog&rsquo;s teeth, grafted immediately after extractions can be considered a suitable biomaterial for socket preservation.

KEYWORDS:

Smart Dentin Grinder; autogenous particulate tooth graft; dog study; socket preservation; tooth particles

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