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Dement Geriatr Cogn Disord. 2018;45(3-4):131-151. doi: 10.1159/000486546. Epub 2018 May 7.

A Systematic Review and Meta-Analysis of the Effectiveness of Acetylcholinesterase Inhibitors and Memantine in Treating the Cognitive Symptoms of Dementia.

Author information

1
Department of Biostatistics and Health Informatics, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
2
Norwich Medical School, University of East Anglia, Norwich, United Kingdom.
3
Department of Psychological Medicine, Institute of Psychiatry, Psychology and Neuroscience, King's College London, London, United Kingdom.
4
South London and Maudsley NHS Foundation Trust, London, United Kingdom.

Abstract

BACKGROUND:

Acetylcholinesterase inhibitors (AChEIs) and memantine are commonly used in the management of dementia. In routine clinical practice, dementia is often monitored via the Mini-Mental State Examination (MMSE). We conducted a systematic review and meta-analysis of the effects of these drugs on MMSE scores.

SUMMARY:

Eighty trials were identified. Pooled effect estimates were in favour of both AChEIs and memantine at 6 months. Meta-regression indicated that dementia subtype was a moderator of AChEI treatment effect, with the effect of treatment versus control twice as high for patients with Parkinson disease dementia/ dementia with Lewy bodies (2.11 MMSE points at 6 months) as for patients with Alzheimer disease/vascular dementia (0.91 MMSE points at 6 months). Key Messages: AChEIs demonstrate a modest effect versus control on MMSE scores which is moderated by dementia subtype. For memantine the effect is smaller.

KEYWORDS:

Acetylcholinesterase inhibitor; Alzheimer disease; Memantine; Meta-analysis; Systematic review; Vascular dementia

PMID:
29734182
DOI:
10.1159/000486546
[Indexed for MEDLINE]
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