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Eur Psychiatry. 2018 Aug;52:68-75. doi: 10.1016/j.eurpsy.2018.04.001. Epub 2018 May 4.

Obstetric and perinatal health outcomes related to schizophrenia: A national register-based follow-up study among Finnish women born between 1965 and 1980 and their offspring.

Author information

1
Helsinki University and Helsinki University Hospital, Psychiatry, P.O. Box 590, 00029 HUS, Helsinki, Finland. Electronic address: laura.simoila@hus.fi.
2
Helsinki University and Helsinki University Hospital, Psychiatry, P.O. Box 590, 00029 HUS, Helsinki, Finland. Electronic address: erkki.isometsa@hus.fi.
3
National Institute for Health and Welfare, Information Services Department, Mannerheimintie 166, 00270 Helsinki, Finland; Research Centre for Child Psychiatry, University of Turku, Lemminkäisenkatu 3, 20520 Turku, Finland; Karolinska Institute, Department of Neurobiology, Care Sciences and Society, Division of Family Medicine, Alfred Nobels allé 23, 14183 Huddinge, Sweden. Electronic address: mika.gissler@thl.fi.
4
National Institute for Health and Welfare, Mental Health Unit, P.O. Box 30, 00271 Helsinki, Finland. Electronic address: jaana.suvisaari@thl.fi.
5
Helsinki University and Helsinki University Hospital, Obstetrics and Gynecology, P.O. Box 140, 00029 HUS, Helsinki, Finland; Femeda-clinic, Kalevankatu 9 A, 00100 Helsinki, Finland. Electronic address: erja.halmesmaki@kolumbus.fi.
6
Helsinki University and Helsinki University Hospital, Forensic Psychiatry, P.O. Box 590, 00029 HUS, Helsinki, Finland. Electronic address: nina.lindberg@hus.fi.

Abstract

BACKGROUND:

This national register-based study assesses obstetric and perinatal health outcomes in women with schizophrenia and their offspring.

METHODS:

Using the Care Register for Health Care, we identified Finnish women who were born in 1965- 1980 and diagnosed with schizophrenia. For each case, five age- and place-of-birth- matched controls were obtained from the Central Population Register of Finland. They were followed from the day when the disorder was diagnosed in specialized health-care (the index day) until 31.12.2013. Information related to births was obtained from the Medical Birth Register and the Register of Congenital Malformations. We focused on singleton pregnancies that led to a delivery after the index day. We restricted the analysis of deliveries in controls to those that occurred after the index day of the case. Maternal age, marital status, smoking status, sex of the newborn, and parity were used as covariates in adjusted models.

RESULTS:

We identified 1162 singleton births among women with schizophrenia and 4683 among controls. Schizophrenic women had a 1.4-fold increased risk of induction of labor, delivery by cesarean section, and delivery by elective cesarean section. Regarding offspring, the risk of premature birth and the risk of low Apgar score at 1 min (<7) were 1.6-fold, of resuscitation 2.5-fold, and of neonatal monitoring 2.1-fold higher.

CONCLUSIONS:

Schizophrenia associates with some specific delivery methods, but delivery complications are rare and their prevalence does not differ from that observed among community women. Maternal schizophrenia associates with some negative perinatal health outcomes of the offspring.

KEYWORDS:

Delivery; Postpartum period; Pregnancy; Schizoaffective disorder; Schizophrenia

PMID:
29734128
DOI:
10.1016/j.eurpsy.2018.04.001
[Indexed for MEDLINE]

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