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JACC Basic Transl Sci. 2018 Feb;3(1):83-96. doi: 10.1016/j.jacbts.2017.09.004.

Rad GTPase deletion attenuates post-ischemic cardiac dysfunction and remodeling.

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Department of Physiology, University of Kentucky, Lexington KY.
Department of Biochemistry, University of Kentucky, Lexington KY.
Saha Cardiovascular Research Center, Department of Medicine, University of Kentucky, Lexington, KY.
Gill Heart and Vascular Institute, University of Kentucky, Lexington KY.
Department of Nutrition Sciences, University of Alabama, Birmingham AL.
Department of Imaging Science and Innovation, Geisinger, Danville PA.
Center for Translational Medicine, Temple University School of Medicine, Philadelphia PA.


The protein Rad interacts with the LTCC to modulate trigger Ca2+, hence to govern contractility. Reducing Rad levels increases cardiac output. Ablation of Rad also attenuated the inflammatory response following acute myocardial infarction (AMI). Future studies to target deletion of Rad in the heart could be conducted to establish a novel treatment paradigm whereby pathologically stressed hearts would be given a safe, stable positive inotropic support without arrhythmias and without pathological structural remodeling. Future investigations will also focus on establishing inhibitors of Rad, and testing the efficacy of Rad-deletion in cardioprotection relative to the time of onset of AMI.

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