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BMJ Open. 2018 May 5;8(5):e020640. doi: 10.1136/bmjopen-2017-020640.

Cohort profile: The MULTI sTUdy Diabetes rEsearch (MULTITUDE) consortium.

Author information

1
Center for Clinical Translational Epidemiology and Comparative Effectiveness Research, Boston University School of Medicine, Boston, Massachusetts, USA.
2
Department of Medicine, Section of Preventive Medicine and Epidemiology, Boston University School of Medicine, Boston, Massachusetts, USA.
3
Department of Obstetrics and Gynecology, Boston University Medical Campus, Boston, Massachusetts, USA.
4
Department of Physiology and Biophysics, Boston University School of Medicine, Boston, Massachusetts, USA.
5
Department of Epidemiology, Boston University School of Public Health, Boston, Massachusetts, USA.
6
Institute of Global Health, University of Geneva, Geneva, Switzerland.
7
School of Statistics and Mathematics, Central University of Finance and Economics, Beijing, China.
8
Framingham Heart Study, Boston University's and National Heart, Lung, and Blood Institute's Framingham Heart Study, Boston, Massachusetts, USA.
9
Department of Medicine, School of Medicine, Boston University, Boston, Massachusetts, USA.
10
Department of Biostatistics and Epidemiology, School of Public Health, Boston University, Boston, Massachusetts, USA.
11
Obesity Research Center, Department of Medicine, Boston University School of Medicine, Boston, Massachusetts, USA.
12
Community Health Sciences, Boston University School of Public Health, Boston, MA, USA.
#
Contributed equally

Abstract

PURPOSE:

Globally, the age-standardised prevalence of type 2 diabetes mellitus (T2DM) has nearly doubled from 1980 to 2014, rising from 4.7% to 8.5% with an estimated 422 million adults living with the chronic disease. The MULTI sTUdy Diabetes rEsearch (MULTITUDE) consortium was recently established to harmonise data from 17 independent cohort studies and clinical trials and to facilitate a better understanding of the determinants, risk factors and outcomes associated with T2DM.

PARTICIPANTS:

Participants range in age from 3 to 88 years at baseline, including both individuals with and without T2DM. MULTITUDE is an individual-level pooled database of demographics, comorbidities, relevant medications, clinical laboratory values, cardiac health measures, and T2DM-associated events and outcomes across 45 US states and the District of Columbia.

FINDINGS TO DATE:

Among the 135 156 ongoing participants included in the consortium, almost 25% (33 421) were diagnosed with T2DM at baseline. The average age of the participants was 54.3, while the average age of participants with diabetes was 64.2. Men (55.3%) and women (44.6%) were almost equally represented across the consortium. Non-whites accounted for 31.6% of the total participants and 40% of those diagnosed with T2DM. Fewer individuals with diabetes reported being regular smokers than their non-diabetic counterparts (40.3% vs 47.4%). Over 85% of those with diabetes were reported as either overweight or obese at baseline, compared with 60.7% of those without T2DM. We observed differences in all-cause mortality, overall and by T2DM status, between cohorts.

FUTURE PLANS:

Given the wide variation in demographics and all-cause mortality in the cohorts, MULTITUDE consortium will be a unique resource for conducting research to determine: differences in the incidence and progression of T2DM; sequence of events or biomarkers prior to T2DM diagnosis; disease progression from T2DM to disease-related outcomes, complications and premature mortality; and to assess race/ethnicity differences in the above associations.

KEYWORDS:

cardiac epidemiology; epidemiology; preventive medicine

PMID:
29730626
PMCID:
PMC5942412
DOI:
10.1136/bmjopen-2017-020640
[Indexed for MEDLINE]
Free PMC Article

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