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Neurosci Biobehav Rev. 2018 Jul;90:400-410. doi: 10.1016/j.neubiorev.2018.04.022. Epub 2018 May 3.

Towards a human self-regulation system: Common and distinct neural signatures of emotional and behavioural control.

Author information

1
Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-7: Brain & Behaviour), Research Centre Jülich, D-52425 Jülich, Germany. Electronic address: robert.langner@hhu.de.
2
Laboratory for Social and Neural Systems Research, Department of Economics, University of Zurich, CH-8006 Zurich, Switzerland; Ambulatorium Lenzburg Klinik im Hasel CH-5600 Lenzburg Switzerland.
3
Institute of Systems Neuroscience, Medical Faculty, Heinrich Heine University Düsseldorf, D-40225 Düsseldorf, Germany; Institute of Neuroscience and Medicine (INM-7: Brain & Behaviour), Research Centre Jülich, D-52425 Jülich, Germany.

Abstract

Self-regulation refers to controlling our emotions and actions in the pursuit of higher-order goals. Although research suggests commonalities in the cognitive control of emotion and action, evidence for a shared neural substrate is scant and largely circumstantial. Here we report on two large-scale meta-analyses of human neuroimaging studies on emotion or action control, yielding two fronto-parieto-insular networks. The networks' overlap, however, was restricted to four brain regions: posteromedial prefrontal cortex, bilateral anterior insula, and right temporo-parietal junction. Conversely, meta-analytic contrasts revealed major between-network differences, which were independently corroborated by clustering domain-specific regions based on their intrinsic functional connectivity, as well as by functionally characterizing network sub-clusters using the BrainMap database for quantitative forward and reverse inference. Collectively, our analyses identified a core system for implementing self-control across emotion and action, beyond which, however, either regulation facet appears to rely on broadly similar yet distinct subnetworks. These insights into the neurocircuitry subserving affective and executive facets of self-control suggest both processing commonalities and differences between the two aspects of human self-regulation.

KEYWORDS:

ALE meta-analysis; Cognitive control; Control theory; Emotion regulation; Executive functions; Functional decoding; Resting-state fMRI

PMID:
29730485
PMCID:
PMC5994341
DOI:
10.1016/j.neubiorev.2018.04.022
[Indexed for MEDLINE]
Free PMC Article

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