Format

Send to

Choose Destination
Prog Retin Eye Res. 2018 Nov;67:56-86. doi: 10.1016/j.preteyeres.2018.04.006. Epub 2018 May 4.

A new perspective on lipid research in age-related macular degeneration.

Author information

1
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands.
2
Centre for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom.
3
Univ. Bordeaux, Inserm, Bordeaux Population Health Research Center, Team LEHA, UMR 1219, F-33000, Bordeaux, France.
4
Department of Ophthalmology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands.
5
Centre for Ophthalmology, Institute for Ophthalmic Research, University of Tübingen, Germany.
6
UCL Institute of Ophthalmology, London, United Kingdom.
7
Barcelona Macula Foundation, Barcelona, Spain.
8
Department of Epidemiology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Ophthalmology, Erasmus Medical Center, Rotterdam, The Netherlands; Department of Ophthalmology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands.
9
Roche Innovation Center Basel, F. Hoffmann-La Roche Ltd, Basel, Switzerland.
10
Department of Ophthalmology, Radboud University Medical Center, Donders Institute for Brain, Cognition and Behavior, Nijmegen, The Netherlands; Department of Human Genetics, Radboud University Medical Center, Nijmegen, The Netherlands.
11
Centre for Experimental Medicine, Queen's University Belfast, Belfast, United Kingdom. Electronic address: i.lengyel@qub.ac.uk.

Abstract

There is an urgency to find new treatment strategies that could prevent or delay the onset or progression of AMD. Different classes of lipids and lipoproteins metabolism genes have been associated with AMD in a multiple ways, but despite the ever-increasing knowledge base, we still do not understand fully how circulating lipids or local lipid metabolism contribute to AMD. It is essential to clarify whether dietary lipids, systemic or local lipoprotein metabolismtrafficking of lipids in the retina should be targeted in the disease. In this article, we critically evaluate what has been reported in the literature and identify new directions needed to bring about a significant advance in our understanding of the role for lipids in AMD. This may help to develop potential new treatment strategies through targeting the lipid homeostasis.

KEYWORDS:

Age-related macular degeneration (AMD); Circulating lipoproteins; Dietary lipids; Genetics; High-density lipoprotein cholesterol (HDL-C); Retinal lipids

Free full text

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center