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Zhongguo Zhong Yao Za Zhi. 2018 Apr;43(7):1404-1409. doi: 10.19540/j.cnki.cjcmm.20180312.006.

[¹H-NMR quantitative analysis and fingerprints of ginkgo diterpene lactone raw material].

[Article in Chinese]
Chen XL1,2, Geng T1,2, Huang WZ1,2, Wang ZZ1,2, Xiao W1,2.

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Jiangsu Kanion Parmaceutical Co., Ltd., Lianyungang 222001, China.
State Key Laboratory of New-tech for Chinese Medicine Pharmaceutical Process, Lianyungang 222001, China.


Ginkgo diterpene lactone raw material, as a raw material for ginkgo diterpene lactone meglumine injection, is extracted and purified from ginkgo leaf. ¹H-NMR content determination method and fingerprint analysis method were respectively established for ginkgo diterpene lactone raw material. Content determination was conducted in 3 batches of samples by using ¹H-qNMR, and then the results were basically consistent with the results in HPLC method. Twenty-four proton peaks were identified as common fingerprint peaks, and the fingerprint peaks were identified by using the control product and NMR information. Furthermore, 10 batches of samples were analyzed by ¹H-NMR fingerprint. The similarities were all higher than 0.99 and the common peaks were identified with the reference standards. This method is easy, fast, with good precision, stability and repeatability and could provide basis and new ideas for quality evaluation of ginkgo diterpene lactone raw material and its preparations.


fingerprint ; ginkgo diterpene lactone raw material ; quality evaluation ; quantitative analysis ; ¹H-NMR

Conflict of interest statement

The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.

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