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Nat Prod Res. 2018 May 4:1-5. doi: 10.1080/14786419.2018.1468327. [Epub ahead of print]

Structural characterization and immunosuppressive activity of a new pregnane glycoside from Epigynum cochinchinensis.

Author information

1
a Yunnan Institute of Food Safety, Kunming University of Science and Technology , Kunming , People's Republic of China.
2
b First People's Hospital of Yunnan Province , The Affiliated Hospital of Kunming University of Science and Technology , Kunming , People's Republic of China.
3
c Department of Chemistry , COMSATS Institute of Information Technology , Abbottabad , Pakistan.

Abstract

Phytochemical investigation on the ethyl acetate fraction of the leaves of Epigynum cochinchinensis led to the isolation of a new C21 pregnane glycoside, epigycoside B (1), together with three known analogues. Their structures were elucidated on the basis of extensive spectroscopic techniques, including UV, MS, and NMR experiments, as well as the chemical methods. Compound 1 displayed in vitro immunosuppressive activity against concanavalin A (Con A)/Lipopolysaccharides (LPS)-stimulated proliferation of mice splenocyte. The activity was significant as compared with control group at 50 μM concentration.

KEYWORDS:

Epigynum cochinchinensis; epigycoside B; immunosuppressive; pregnane glycoside

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