Abstract
Juglonols A-C (1-3), three new juglone derivatives possessing a hydroxyethyl side chain, were isolated from an organic extract of the immature exocarps of Juglans mandshurica together with five known tetralones (4-8). Their structures were elucidated by extensive spectroscopic analyses and comparison with literature data. The new juglone derivatives exhibited inhibitory activities towards a panel of bacteria and fungi, as well as cancer cell lines. In contrast, the known tetralone homologues (4-8) appeared to be much less efficacy.
Keywords:
juglone; juglonols A−C; tetralone.
MeSH terms
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Anti-Bacterial Agents / chemistry
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Anti-Bacterial Agents / isolation & purification
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Anti-Bacterial Agents / pharmacology
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Anti-Infective Agents / isolation & purification*
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Anti-Infective Agents / pharmacology
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Antifungal Agents / chemistry
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Antifungal Agents / isolation & purification
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Antifungal Agents / pharmacology
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Antineoplastic Agents / chemistry
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Antineoplastic Agents / isolation & purification
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Antineoplastic Agents / pharmacology
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Cell Line
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Humans
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Juglans / chemistry*
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Molecular Structure
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Naphthoquinones / isolation & purification
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Naphthoquinones / pharmacology*
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Naphthoquinones / toxicity
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Plant Extracts / chemistry*
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Plant Extracts / pharmacology
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Spectrum Analysis / methods
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Tetralones / isolation & purification
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Tetralones / pharmacology
Substances
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Anti-Bacterial Agents
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Anti-Infective Agents
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Antifungal Agents
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Antineoplastic Agents
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Naphthoquinones
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Plant Extracts
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Tetralones
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juglone