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Brain Struct Funct. 2018 Jul;223(6):2949-2971. doi: 10.1007/s00429-018-1671-8. Epub 2018 May 3.

Connectivity of neuronal populations within and between areas of primate somatosensory cortex.

Author information

1
Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary.
2
Complex Systems and Computational Neuroscience Group, Wigner Research Centre for Physics, Hungarian Academy of Sciences, Konkoly-Thege Miklós út 29-33, Budapest, 1121, Hungary.
3
Department of Physiology and Biochemistry, Faculty of Veterinary Science, Szent István University, Budapest, 1078, Hungary.
4
Division of Biology and Biological Engineering, California Institute of Technology, Pasadena, CA, 91125, USA.
5
Department of Mathematical Sciences, University of Montana, Missoula, MT, 59812, USA.
6
Department of Neuroanatomy, Faculty of Medicine, Institute of Anatomy and Cell Biology, University of Freiburg, 79104, Freiburg, Germany.
7
Division of Neuroscience, Oregon Health and Science University, Portland, OR, 97006, USA.
8
Interdisciplinary Institute of Neuroscience and Technology, Zhejiang University, Hangzhou, 310029, China.
9
Department of Anatomy, Histology and Embryology, Semmelweis University, Budapest, 1094, Hungary. negyessy.laszlo@wigner.mta.hu.
10
Complex Systems and Computational Neuroscience Group, Wigner Research Centre for Physics, Hungarian Academy of Sciences, Konkoly-Thege Miklós út 29-33, Budapest, 1121, Hungary. negyessy.laszlo@wigner.mta.hu.

Abstract

Functions of the cerebral cortex emerge via interactions of horizontally distributed neuronal populations within and across areas. However, the connectional underpinning of these interactions is not well understood. The present study explores the circuitry of column-size cortical domains within the hierarchically organized somatosensory cortical areas 3b and 1 using tract tracing and optical intrinsic signal imaging (OIS). The anatomical findings reveal that feedforward connections exhibit high topographic specificity, while intrinsic and feedback connections have a more widespread distribution. Both intrinsic and inter-areal connections are topographically oriented across the finger representations. Compared to area 3b, the low clustering of connections and small cortical magnification factor supports that the circuitry of area 1 scaffolds a sparse functional representation that integrates peripheral information from a large area that is fed back to area 3b. Fast information exchange between areas is ensured by thick axons forming a topographically organized, reciprocal pathway. Moreover, the highest density of projecting neurons and groups of axon arborization patches corresponds well with the size and locations of the functional population response reported by OIS. The findings establish connectional motifs at the mesoscopic level that underpin the functional organization of the cerebral cortex.

KEYWORDS:

Cortical hierarchy; Cortical magnification; Horizontal connections; Optical intrinsic signal imaging; Tract tracing

PMID:
29725759
DOI:
10.1007/s00429-018-1671-8
[Indexed for MEDLINE]

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