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Science. 2018 May 25;360(6391):881-888. doi: 10.1126/science.aar4237. Epub 2018 May 3.

Evolution of pallium, hippocampus, and cortical cell types revealed by single-cell transcriptomics in reptiles.

Author information

1
Max Planck Institute for Brain Research, Max-von-Laue Strasse 4, 60438 Frankfurt am Main, Germany. gilles.laurent@brain.mpg.de maria.tosches@brain.mpg.de.
2
Max Planck Institute for Brain Research, Max-von-Laue Strasse 4, 60438 Frankfurt am Main, Germany.

Abstract

Computations in the mammalian cortex are carried out by glutamatergic and γ-aminobutyric acid-releasing (GABAergic) neurons forming specialized circuits and areas. Here we asked how these neurons and areas evolved in amniotes. We built a gene expression atlas of the pallium of two reptilian species using large-scale single-cell messenger RNA sequencing. The transcriptomic signature of glutamatergic neurons in reptilian cortex suggests that mammalian neocortical layers are made of new cell types generated by diversification of ancestral gene-regulatory programs. By contrast, the diversity of reptilian cortical GABAergic neurons indicates that the interneuron classes known in mammals already existed in the common ancestor of all amniotes.

PMID:
29724907
DOI:
10.1126/science.aar4237
[Indexed for MEDLINE]

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