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Trends Cell Biol. 2018 Sep;28(9):698-708. doi: 10.1016/j.tcb.2018.04.001. Epub 2018 Apr 30.

Vitamin C in Stem Cell Reprogramming and Cancer.

Author information

1
Department of Pathology, New York University (NYU) School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA. Electronic address: luisa.cimmino@nyumc.org.
2
Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA.
3
Department of Pathology, New York University (NYU) School of Medicine, New York, NY 10016, USA; Laura and Isaac Perlmutter Cancer Center, NYU School of Medicine, New York, NY 10016, USA. Electronic address: iannis.aifantis@nyumc.org.

Abstract

Vitamin C is an essential dietary requirement for humans. In addition to its known role as an antioxidant, vitamin C is a cofactor for Fe2+- and α-ketoglutarate-dependent dioxygenases (Fe2+/α-KGDDs) which comprise a large number of diverse enzymes, including collagen prolyl hydroxylases and epigenetic regulators of histone and DNA methylation. Vitamin C can modulate embryonic stem cell (ESC) function, enhance reprogramming of fibroblasts to induced pluripotent stem cells (iPSCs), and hinder the aberrant self-renewal of hematopoietic stem cells (HSCs) through its ability to enhance the activity of either Jumonji C (JmjC) domain-containing histone demethylases or ten-eleven translocation (TET) DNA hydroxylases. Given that epigenetic dysregulation is a known driver of malignancy, vitamin C may play a novel role as an epigenetic anticancer agent.

KEYWORDS:

TET proteins; cancer; epigenetics; methylation; stem cells; vitamin C

PMID:
29724526
PMCID:
PMC6102081
[Available on 2019-09-01]
DOI:
10.1016/j.tcb.2018.04.001

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