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Mol Biol Evol. 2018 Jun 1;35(6):1366-1371. doi: 10.1093/molbev/msy092.

The Neutral Theory in Light of Natural Selection.

Author information

1
Department of Genetics, Rutgers University, Piscataway, NJ.
2
Department of Biology and Department of Computer Science, Indiana University Bloomington, IN.

Abstract

In this perspective, we evaluate the explanatory power of the neutral theory of molecular evolution, 50 years after its introduction by Kimura. We argue that the neutral theory was supported by unreliable theoretical and empirical evidence from the beginning, and that in light of modern, genome-scale data, we can firmly reject its universality. The ubiquity of adaptive variation both within and between species means that a more comprehensive theory of molecular evolution must be sought.

PMID:
29722831
PMCID:
PMC5967545
DOI:
10.1093/molbev/msy092
[Indexed for MEDLINE]
Free PMC Article

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