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J Eukaryot Microbiol. 2018 Nov;65(6):934-939. doi: 10.1111/jeu.12631. Epub 2018 May 25.

The 14th International Workshops on Opportunistic Protists (IWOP 14).

Author information

1
Department of Internal Medicine, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267.
2
Veterans Administration Medical Center, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45220.
3
Thoracic Diseases Research Unit, Department of Medicine, Mayo Clinic College of Medicine, Rochester, Minnesota, 55905.
4
Center for Autoimmune Genomics and Etiology, and Division of Biomedical Informatics, Cincinnati Children's Hospital Medical Center, Cincinnati, Ohio, 45229.
5
Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, Ohio, 45267.
6
Department of Pediatrics, Stanford University of Medicine, Stanford, California, 94305.
7
Department of Microbiology Immunology and Molecular Genetics, University of Kentucky College of Medicine, Lexington, Kentucky, 40536.
8
Departments of Medicine and Pathology, Albert Einstein College of Medicine, Bronx, New York, 10461.

Abstract

The 14th International Workshops on Opportunistic Protists (IWOP-14) was held August 10-12, 2017 in Cincinnati, OH, USA. The IWOP meetings focus on opportunistic protists (OIs); for example, free-living amoebae, Pneumocystis spp., Cryptosporidium spp., Toxoplasma, the Microsporidia, and kinetoplastid flagellates. The highlights of Pneumocystis spp. research included the reports of primary homothallism for mating; a potential requirement for sexual replication in its life cycle; a new antigen on the surface of small asci; roles for CLRs, Dectin-1, and Mincle in host responses; and identification of MSG families and mechanisms used for surface variation. Studies of Cryptosporidia spp. included comparative genomics, a new cryopreservation method; the role of mucin in attachment and invasion, and epidemiological surveys illustrating species diversity in animals. One of the five identified proteins in the polar tube of Microsporidia, PTP4, was shown to play a role in host infection. Zebrafish were used as a low cost vertebrate animal model for an evaluation of potential anti-toxoplasma drugs. Folk medicine compounds with anti-toxoplasma activity were presented, and reports on the chronic toxoplasma infection provided evidence for increased tractability for the study of this difficult life cycle stage. Escape from the parasitophorus vacuole and cell cycle regulation were the topics of the study in the acute phase.

KEYWORDS:

Cryptosporidium ; HIV ; PCP ; Pneumocystis ; Toxoplasma gondii ; Microsporidia; Naegleria; opportunistic infections; pneumonia

PMID:
29722096
PMCID:
PMC6215512
[Available on 2019-11-01]
DOI:
10.1111/jeu.12631

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