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Protein Sci. 2018 Aug;27(8):1450-1463. doi: 10.1002/pro.3438. Epub 2018 Jun 13.

Functional and evolutionary analysis of viral proteins containing a Rossmann-like fold.

Author information

1
Departments of Biophysics and Biochemistry, University of Texas Southwestern Medical Center, Dallas, Texas.
2
Howard Hughes Medical Institute, University of Texas Southwestern Medical Center, Dallas, Texas.

Abstract

Viruses are the most abundant life form and infect practically all organisms. Consequently, these obligate parasites are a major cause of human suffering and economic loss. Rossmann-like fold is the most populated fold among α/β-folds in the Protein Data Bank and proteins containing Rossmann-like fold constitute 22% of all known proteins 3D structures. Thus, analysis of viral proteins containing Rossmann-like domains could provide an understanding of viral biology and evolution as well as could propose possible targets for antiviral therapy. We provide functional and evolutionary analysis of viral proteins containing a Rossmann-like fold found in the evolutionary classification of protein domains (ECOD) database developed in our lab. We identified 81 protein families of bacterial, archeal, and eukaryotic viruses in light of their evolution-based ECOD classification and Pfam taxonomy. We defined their functional significance using enzymatic EC number assignments as well as domain-level family annotations.

KEYWORDS:

Rossmann-like fold; evolution; viral proteins

PMID:
29722076
PMCID:
PMC6153405
DOI:
10.1002/pro.3438
[Indexed for MEDLINE]
Free PMC Article

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