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Naunyn Schmiedebergs Arch Pharmacol. 2018 Aug;391(8):783-791. doi: 10.1007/s00210-018-1495-3. Epub 2018 May 2.

Curcumin protects heart tissue against irinotecan-induced damage in terms of cytokine level alterations, oxidative stress, and histological damage in rats.

Author information

1
Department of Medical Pharmacology, Faculty of Medicine, University of Pamukkale, 20160, Denizli, Turkey. osmciftci@gmail.com.
2
Department of Pharmaceutical Toxicology, Faculty of Pharmacy, University of Inonu, 44280, Malatya, Turkey.
3
Department of Histology and Embryology, Faculty of Medicine, University of Inonu, 44280, Malatya, Turkey.

Abstract

Irinotecan (CPT-11), commonly used in the treatment of many cancer types, may have several side effects that limit the use of CPT-11 in specific tissues such as the heart. In the current study, positive effects of curcumin (CRC) was determined in terms of antioxidant and anti-inflammatory properties against heart damage, caused by CPT-11, in rats. Rats were divided randomly into four equal groups (Control, CPT-11, CRC, and CPT-11 + CRC). CPT-11 10 mg/kg/day was administered intraperitoneally and CRC 100 mg/kg-1 was given orally. Blood and tissue samples were collected from all groups at day 30 for the detection of oxidative stress, histological changes, and cytokine levels. Results showed that CPT-11 caused dramatic changes in heart tissue for oxidative stress parameters (TBARS, SOD, CAT, GSH, and GPx levels), histological tissue damage, and cytokine levels (TNF and IL-4). CRC therapy reversed the elevated oxidative stress, histological tissue damages, and immunological changes and protected cardiac tissue against CPT-11 toxicity when given together with CPT-11.In conclusion, CPT-11 caused adverse effects on cytokine levels, histological alterations, and oxidative stress in rats. However, CRC treatment eliminated these toxic effects with its antioxidant and anti-inflammatory properties. Thus, these results suggest that CRC may play a protective role against CPT-11 toxicity in heart tissue of rats.

KEYWORDS:

Curcumin; Cytokine; Histological alterations; Irinotecan; Oxidative stress

PMID:
29721577
DOI:
10.1007/s00210-018-1495-3
[Indexed for MEDLINE]

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