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Food Nutr Res. 2018 Apr 20;62. doi: 10.29219/fnr.v62.1371. eCollection 2018.

Antioxidant effects of compound walnut oil capsule in mice aging model induced by D-galactose.

Author information

1
Key Laboratory of Nanobiological Technology of Chinese Ministry of Health, Xiangya Hospital, Central South University, Changsha, China.
2
School of Pharmaceutical Sciences, Central South University, Changsha, China.
3
Institute of Biomedical Engineering, Xiangya Hospital, Central South University, Changsha, China.
4
Department of Clinical Laboratory, Xiangya Hospital, Central South University, Changsha, China.
5
Cancer Research Institute, Collaborative Innovation Center for Cancer Medicine, Key Laboratory for Carcinogenesis of Chinese Ministry of Health, School of Basic Medical Science, Central South University, Changsha, China.

Abstract

Background:

Many plant original foods have been shown beneficial effects in humans. In the previous work, we have developed a compound capsule which contains major constituents of walnut oil and grape seed extract.

Objective:

To investigate the antioxidant effects of the Compound Walnut Oil Capsule (WOC) in aging model induced by D-gal.

Design:

70 C57BL/6J mice were randomly divided into seven groups. Mice in normal group received daily subcutaneous injection of saline while the control group, WOC groups, Vitamin C (VC) group and pure walnut oil group received daily subcutaneous injection of D-galactose (D-gal) for 8 weeks. Total antioxidant capacity (T-AOC), super dismutase (SOD), glutathione peroxidase (GSH-Px) and malondialdehyde (MDA) in serum, liver and brain were determined. The expression of Heme Oxygenase (HO-1), iNOS and Klotho in liver and brain were obtained.

Results:

WOC could improve the pathologic lesions caused by oxidative stress and significantly enhance the T-AOC, increase the activities of SOD, GSH-Px and decrease the contents of MDA in serum, liver and brain. Also, the WOC could obviously up-regulate the expression of HO-1 and Klotho and down-regulate the expression of iNOS.

Conclusion:

WOC can be used as an anti-aging food for its effectively eliminating free radicals, enhancing the antioxidant capacity and alleviating the damages of oxidative stress.

KEYWORDS:

D-galactose; aging model; antioxidant; oxidative stress; walnut oil capsule

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