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J Ginseng Res. 2018 Apr;42(2):225-228. doi: 10.1016/j.jgr.2017.02.002. Epub 2017 Feb 28.

Ginsenoside Rg5 prevents apoptosis by modulating heme-oxygenase-1/nuclear factor E2-related factor 2 signaling and alters the expression of cognitive impairment-associated genes in thermal stress-exposed HT22 cells.

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Department of Food Science and Biotechnology, College of Life Science, CHA University, Seongnam, Kyonggi, Republic of Korea.


Our results suggested that thermal stress can lead to activation of hippocampal cell damage and reduction of memory-associated molecules in HT22 cells. These findings also provide a part of molecular rationale for the role of ginsenoside Rg5 as a potent cognitive impairment preventive compound in blocking the initiation of hippocampal damage.


Ginsenoside Rg5; HT22; cognitive impairment; neuroprotection; thermal stress

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