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J Pediatric Infect Dis Soc. 2018 Aug 17;7(3):e145-e147. doi: 10.1093/jpids/pix086.

Caution Needed: Molecular Diagnosis of Pediatric Group A Streptococcal Pharyngitis.

Author information

1
Department of Pediatrics, Ann & Robert H. Lurie Children's Hospital of Chicago, Illinois.
2
Department of Northwestern University Feinberg School of Medicine, Chicago, Illinois.
3
Department of Pathology, Ann & Robert H. Lurie Children's Hospital of Chicago, Illinois.

Abstract

Among throat swabs processed in the microbiology laboratory as back-up for negative rapid antigen detection test results, we found a significant increase in the proportion that tested positive for group A streptococci after changing from throat culture to a molecular test.For group A streptococcus testing, our hospital laboratory replaced throat cultures with a stand-alone molecular diagnostic test that takes no more than 1 hour to perform. The prevalence of positive laboratory test results increased significantly (P < .0001) after the change to molecular testing, probably because of the extreme sensitivity of the molecular test.

PMID:
29718302
DOI:
10.1093/jpids/pix086
[Indexed for MEDLINE]

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