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J Nutr Health Aging. 2018;22(5):608-612. doi: 10.1007/s12603-018-1021-9.

Selenium Concentrations and Mortality among Community-Dwelling Older Adults: Results from IlSIRENTE Study.

Author information

1
Silvia Giovannini, MD, PhD, Department of Geriatrics, Neurosciences, and Orthopaedics, Catholic University of Medicine, A. Gemelli Foundation, Catholic University School of Medicine, Rome, Italy, E-mail: silvia_giovannini@yahoo.it, Telephone: +390630154341, Fax: +39063051911.

Abstract

BACKGROUND:

Selenium has a wide range of pleiotropic effects, influencing redox homeostasis, thyroid hormone metabolism, and protecting from oxidative stress and inflammation. Serum selenium levels are reduced in the older population.

OBJECTIVES:

to investigate the association of serum selenium levels with all-cause mortality in a sample of community-dwelling older adults.

DESIGN AND SETTING:

Data are from the 'Invecchiamento e Longevità nel Sirente' (Aging and Longevity in the Sirente geographic area, ilSIRENTE) study, a prospective cohort study that collected information on individuals aged 80 years and older living in an Italian mountain community (n=347). The main outcome was risk of death after ten years of follow-up.

PARTICIPANTS AND MEASUREMENTS:

Participants were classified according to the median value of selenium (105.3 μg/L) in two groups: high selenium and low selenium.

RESULTS:

A total of 248 deaths occurred during a 10-year follow-up. In the unadjusted model, low levels of selenium was associated with increased mortality (HR, 0.66; 95% CI 0.51-0.85). After adjusting for potential confounders the relationship remained significant (HR, 0.71; 95% CI 0.54-0.92).

CONCLUSIONS:

Low serum levels of selenium are associated with reduced survival in elderly, independently of age and other clinical and functional variables.

KEYWORDS:

Selenium ; frail elderly; mortality

PMID:
29717761
DOI:
10.1007/s12603-018-1021-9

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