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Sci Rep. 2018 May 1;8(1):6853. doi: 10.1038/s41598-018-25128-x.

Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry.

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Kaiser Permanente Northern California Division of Research, Oakland, CA, USA.
Kaiser Permanente Northern California Division of Research, Oakland, CA, USA.
GenDiag, Inc/Ferrer in Code, Inc., Barcelona, Spain.
CIBER of Epidemiology and Public Health, Barcelona, Spain.
Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain.
CIBER of Cardiovascular Diseases (CIBERCV), Barcelona, Spain.


We examined the clinical utility of two multi-locus genetic risk scores (GRSs) previously validated in Europeans among persons of African (AFR; n = 2,089), Latino (LAT; n = 4,349) and East-Asian (EA; n = 4,804) ancestry. We used data from the GERA cohort (30-79 years old, 68 to 73% female). We utilized two GRSs with 12 and 51 SNPs, respectively, and the Framingham Risk Score (FRS) to estimate 10-year CHD risk. After a median 8.7 years of follow-up, 450 incident CHD events were documented (95 in AFR, 316 in LAT and 39 EA, respectively). In a model adjusting for principal components and risk factors, tertile 3 vs. tertile 1 of GRS_12 was associated with 1.86 (95% CI, 1.15-3.01), 1.52 (95% CI, 1.02-2.25) and 1.19 (95% CI, 0.77-1.83) increased hazard of CHD in AFR, LAT and EA, respectively. Inclusion of the GRSs in models containing the FRS did not increase the C-statistic but resulted in net overall reclassification of 10% of AFR, 7% LAT and EA and in reclassification of 13% of AFR and EA as well as 10% LAT in the intermediate FRS risk subset. Our results support the usefulness of incorporating genetic information into risk assessment for primary prevention among minority subjects in the U.S.

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