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Sci Rep. 2018 May 1;8(1):6853. doi: 10.1038/s41598-018-25128-x.

Weighted Multi-marker Genetic Risk Scores for Incident Coronary Heart Disease among Individuals of African, Latino and East-Asian Ancestry.

Author information

1
Kaiser Permanente Northern California Division of Research, Oakland, CA, USA. cgi@dor.kaiser.org.
2
Kaiser Permanente Northern California Division of Research, Oakland, CA, USA.
3
GenDiag, Inc/Ferrer in Code, Inc., Barcelona, Spain.
4
CIBER of Epidemiology and Public Health, Barcelona, Spain.
5
Cardiovascular Epidemiology and Genetics, IMIM, Barcelona, Spain.
6
CIBER of Cardiovascular Diseases (CIBERCV), Barcelona, Spain.

Abstract

We examined the clinical utility of two multi-locus genetic risk scores (GRSs) previously validated in Europeans among persons of African (AFR; n = 2,089), Latino (LAT; n = 4,349) and East-Asian (EA; n = 4,804) ancestry. We used data from the GERA cohort (30-79 years old, 68 to 73% female). We utilized two GRSs with 12 and 51 SNPs, respectively, and the Framingham Risk Score (FRS) to estimate 10-year CHD risk. After a median 8.7 years of follow-up, 450 incident CHD events were documented (95 in AFR, 316 in LAT and 39 EA, respectively). In a model adjusting for principal components and risk factors, tertile 3 vs. tertile 1 of GRS_12 was associated with 1.86 (95% CI, 1.15-3.01), 1.52 (95% CI, 1.02-2.25) and 1.19 (95% CI, 0.77-1.83) increased hazard of CHD in AFR, LAT and EA, respectively. Inclusion of the GRSs in models containing the FRS did not increase the C-statistic but resulted in net overall reclassification of 10% of AFR, 7% LAT and EA and in reclassification of 13% of AFR and EA as well as 10% LAT in the intermediate FRS risk subset. Our results support the usefulness of incorporating genetic information into risk assessment for primary prevention among minority subjects in the U.S.

PMID:
29717161
PMCID:
PMC5931622
DOI:
10.1038/s41598-018-25128-x
[Indexed for MEDLINE]
Free PMC Article

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