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Per Med. 2018 Mar;15(2):103-110. doi: 10.2217/pme-2017-0072. Epub 2018 Feb 6.

Association of genetic polymorphisms in immune-related lncRNA with osteoarthritis susceptibility in Chinese Han population.

Author information

1
Department of Orthopedic, The Yixing People's Hospital, Yixing 214200, PR China.

Abstract

AIM:

Immune-related lncRNA may influence osteoarthritis (OA) susceptibility. We conducted this study to assess whether the genetic variants in several immune-related lncRNA influence OA susceptibility.

METHODS:

The current research genotyped four SNPs in 306 OA patients and 316 healthy controls, including PRNCR1 rs7463708, PRNCR1 rs1456315, PRNCR1 rs16901946 and KIF13B1 rs643472, to investigate their associations with OA susceptibility.

RESULTS:

We identified that PRNCR1 rs1456315 was associated with OA susceptibility in Chinese Han population (recessive model: odds ratio = 2.24; 95% CI: 1.05-4.81; additive model: odds ratio = 1.36; 95% CI: 1.03-1.80).

CONCLUSION:

Individuals with PRNCR1 rs1456315 mutant G allele were more likely to suffer from OA in Chinese Han population.

KEYWORDS:

immune response lncRNA; osteoarthritis; polymorphism; predictors; susceptibility

PMID:
29714128
DOI:
10.2217/pme-2017-0072
[Indexed for MEDLINE]

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