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Mediators Inflamm. 2018 Mar 11;2018:9830939. doi: 10.1155/2018/9830939. eCollection 2018.

Intestinal Immunomodulatory Cells (T Lymphocytes): A Bridge between Gut Microbiota and Diabetes.

Li Q1,2, Gao Z1,2, Wang H3, Wu H1,2, Liu Y1,2, Yang Y1,2, Han L1, Wang X1, Zhao L1,4, Tong X1.

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Department of Endocrinology, Guang'anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, China.
Beijing University of Chinese Medicine, Beijing 100029, China.
Shenzhen Hospital, Guangzhou University of Chinese Medicine, Guangzhou 518034, China.
Laboratory of Molecular and Biology, Guang'anmen Hospital of China, Academy of Chinese Medical Sciences, Beijing 100053, China.


Diabetes mellitus (DM) is one of the most familiar chronic diseases threatening human health. Recent studies have shown that the development of diabetes is closely related to an imbalance of the gut microbiota. Accordingly, there is increasing interest in how changes in the gut microbiota affect diabetes and its underlying mechanisms. Immunomodulatory cells play important roles in maintaining the normal functioning of the human immune system and in maintaining homeostasis. Intestinal immunomodulatory cells (IICs) are located in the intestinal mucosa and are regarded as an intermediary by which the gut microbiota affects physiological and pathological properties. Diabetes can be regulated by IICs, which act as a bridge linking the gut microbiota and DM. Understanding this bridge role of IICs may clarify the mechanisms by which the gut microbiota contributes to DM. Based on recent research, we summarize this process, thereby providing a basis for further studies of diabetes and other similar immune-related diseases.

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