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Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30.

Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Author information

1
Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, U.K. Karen.horsburgh@ed.ac.uk.
2
Centre for Clinical Brain Sciences, UK Dementia Research Institute, University of Edinburgh, Edinburgh, U.K.
3
Institute of Cardiovascular and Medical Sciences, University of Glasgow, Glasgow, U.K.
4
Faculty of Biology, Medicine and Health, University of Manchester, Manchester, U.K.
5
School of Medicine, University of Dundee, Dundee, U.K.
6
Stroke Trials Unit, Division of Clinical Neuroscience, University of Nottingham, Nottingham, U.K.
7
Centre for Clinical Brain Sciences, University of Edinburgh, Edinburgh, U.K.
8
Department of Psychology, University of Sheffield, Sheffield, U.K.
9
Nuffield Department of Clinical Neurosciences, University of Oxford, Oxford, UK.
10
Faculty of Medicine, University of Southampton, Southampton, U.K.
11
Alzheimer's Research UK Oxford Drug Discovery Institute, University of Oxford, Oxford, U.K.
12
Centre for Discovery Brain Sciences, University of Edinburgh, Edinburgh, U.K.
13
School of Life Sciences, Nottingham University, Nottingham, U.K.
14
Institute of Neuroscience and Psychology, University of Glasgow, Glasgow, U.K.
15
Department of Clinical Neurosciences, University of Cambridge, Cambridge, U.K.
16
School of Psychology, University of Sussex, Brighton, U.K.
17
Molecular and Clinical Sciences Research Institute, St Georges University of London, London, U.K.
18
Faculty of Science, Technology, Engineering & Mathematics, Open University, Milton Keynes, U.K.
19
Genetics and Pathogenesis of Cerebrovascular Diseases, INSERM, Université Paris Diderot-Paris 7, Paris, France.
20
Institute of Neuroscience, Newcastle University, Newcastle upon Tyne, U.K.
21
Bristol Medical School, University of Bristol, Bristol, U.K.
22
GSK (currently Heptares Therapeutics), U.K.
23
Clinical Neurosciences, University of Bristol, Bristol, U.K.
24
The Roslin Institute & R(D)SVS, UK Dementia Research Institute, University of Edinburgh, Edinburgh, U.K.
25
Division of Molecular & Clinical Medicine, School of Medicine, University of Dundee, Dundee, U.K.
26
University of Rochester Medical Center, Rochester, NY, USA and University of Copenhagen's Center of Basic and Translational Neuroscience, Copenhagen, Denmark.
27
Mater Centre for Neuroscience and Queensland Brain Institute, Brisbane, Australia.
28
Robarts Research Institute, Western University, London, Ontario, Canada.
29
Department of Neuroinflammation, UCL Institute of Neurology, London, U.K.
30
MRC Centre for Regenerative Medicine, University of Edinburgh, Edinburgh, U.K.
31
Institute of Psychiatry, Kings College London, London, U.K.

Abstract

Cerebral small vessel disease (SVD) is a major contributor to stroke, cognitive impairment and dementia with limited therapeutic interventions. There is a critical need to provide mechanistic insight and improve translation between pre-clinical research and the clinic. A 2-day workshop was held which brought together experts from several disciplines in cerebrovascular disease, dementia and cardiovascular biology, to highlight current advances in these fields, explore synergies and scope for development. These proceedings provide a summary of key talks at the workshop with a particular focus on animal models of cerebral vascular disease and dementia, mechanisms and approaches to improve translation. The outcomes of discussion groups on related themes to identify the gaps in knowledge and requirements to advance knowledge are summarized.

KEYWORDS:

cerebral vascular disease; dementia

PMID:
29712883
DOI:
10.1042/CS20171620

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