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J Neurosci. 2018 May 30;38(22):5209-5219. doi: 10.1523/JNEUROSCI.1992-17.2017. Epub 2018 Apr 30.

Conditional Bistability, a Generic Cellular Mnemonic Mechanism for Robust and Flexible Working Memory Computations.

Author information

1
Institut des Systèmes Intelligents et de Robotique, Sorbonne Université, Centre National de la Recherche Scientifique, UMR 7222, 75005 Paris, France.
2
Gladstone Institutes, San Francisco, California 94158.
3
Neurosciences Graduate Program.
4
Department of Neurology, University of California, San Francisco, California, 94158.
5
Kavli Institute for Fundamental Neuroscience, University of California San Francisco.
6
Institut des Systèmes Intelligents et de Robotique, Sorbonne Université, Centre National de la Recherche Scientifique, UMR 7222, 75005 Paris, France, bruno.delord@upmc.fr.

Abstract

Persistent neural activity, the substrate of working memory, is thought to emerge from synaptic reverberation within recurrent networks. However, reverberation models do not robustly explain the fundamental dynamics of persistent activity, including high-spiking irregularity, large intertrial variability, and state transitions. While cellular bistability may contribute to persistent activity, its rigidity appears incompatible with persistent activity labile characteristics. Here, we unravel in a cellular model a form of spike-mediated conditional bistability that is robust and generic. and provides a rich repertoire of mnemonic computations. Under asynchronous synaptic inputs of the awakened state, conditional bistability generates spiking/bursting episodes, accounting for the irregularity, variability, and state transitions characterizing persistent activity. This mechanism has likely been overlooked because of the subthreshold input it requires, and we predict how to assess it experimentally. Our results suggest a reexamination of the role of intrinsic properties in the collective network dynamics responsible for flexible working memory.SIGNIFICANCE STATEMENT This study unravels a novel form of intrinsic neuronal property: conditional bistability. We show that, thanks to its conditional character, conditional bistability favors the emergence of flexible and robust forms of persistent activity in PFC neural networks, in opposition to previously studied classical forms of absolute bistability. Specifically, we demonstrate for the first time that conditional bistability (1) is a generic biophysical spike-dependent mechanism of layer V pyramidal neurons in the PFC and that (2) it accounts for essential neurodynamical features for the organization and flexibility of PFC persistent activity (the large irregularity and intertrial variability of the discharge and its organization under discrete stable states), which remain unexplained in a robust fashion by current models.

KEYWORDS:

conditional bistability; flexible; generic; memory; robust; working memory

PMID:
29712783
PMCID:
PMC6705937
DOI:
10.1523/JNEUROSCI.1992-17.2017
[Indexed for MEDLINE]
Free PMC Article

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