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Cell Cycle. 2018;17(8):963-973. doi: 10.1080/15384101.2018.1442629. Epub 2018 May 31.

Global expression profiling and pathway analysis of mouse mammary tumor reveals strain and stage specific dysregulated pathways in breast cancer progression.

Author information

1
a Department of Experimental Research, State Key Laboratory of Oncology in South China, Collaborative Innovation Center for Cancer Medicine , Sun Yat-Sen University Cancer Center , Guangzhou 510060 , China.
2
b Vascular Biology Research Institute, School of Basic Course, Guangdong Pharmaceutical University , Guangzhou 510006 , China.
3
d Department of Traditional Chinese Medicine , First Affiliated Hospital, Sun Yat-Sen University , Guangzhou , China.
4
e Department of Hematology , The First Affiliated Hospital of Guangzhou Medical University , Guangzhou 510230 , China.
5
c Department of Nasopharyngeal Carcinoma , Sun Yat-Sen University Cancer Center , Guangzhou 510060 , China.

Abstract

It is believed that the alteration of tissue microenvironment would affect cancer initiation and progression. However, little is known in terms of the underlying molecular mechanisms that would affect the initiation and progression of breast cancer. In the present study, we use two murine mammary tumor models with different speeds of tumor initiation and progression for whole genome expression profiling to reveal the involved genes and signaling pathways. The pathways regulating PI3K-Akt signaling and Ras signaling were activated in Fvb mice and promoted tumor progression. Contrastingly, the pathways regulating apoptosis and cellular senescence were activated in Fvb.B6 mice and suppressed tumor progression. We identified distinct patterns of oncogenic pathways activation at different stages of breast cancer, and uncovered five oncogenic pathways that were activated in both human and mouse breast cancers. The genes and pathways discovered in our study would be useful information for other researchers and drug development.

KEYWORDS:

Apoptosis; Breast cancer; Cancer progression; PI3K-Akt signaling; RNA-sequencing; Ras signaling

PMID:
29712537
PMCID:
PMC6103659
[Available on 2019-05-31]
DOI:
10.1080/15384101.2018.1442629

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