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Angew Chem Int Ed Engl. 2001 Aug 3;40(15):2909-2912. doi: 10.1002/1521-3773(20010803)40:15<2909::AID-ANIE2909>3.0.CO;2-O.

Directed Assembly of Periodic Materials from Protein and Oligonucleotide-Modified Nanoparticle Building Blocks.

Author information

1
Department of Chemistry and Center for Nanofabrication and Molecular Self Assembly Northwestern University 2145 Sheridan Road, Evanston, IL 60208-3113 (USA) Fax: (+1) 847-467-5123.
2
Department of Chemistry Northwestern University 2145 Sheridan Road, Evanston, IL 60208-3113 (USA) Fax: (+1) 847-491-2081.

Abstract

DNA hybridization enables the three-dimensional assembly of Au nanoparticles and streptavidin. The high-density DNA-modified Au nanoparticles were stable to nonspecific binding of streptavidin. Structural and melting investigations on the assemblies showed their formation was reversible.

KEYWORDS:

DNA structures; nanostructures; oligonucleotides; proteins; small-angle X-ray scattering

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