Gold Glyconanoparticles as Water-Soluble Polyvalent Models To Study Carbohydrate Interactions

Jesús M de la Fuente; Africa G Barrientos; Teresa C Rojas; Javier Rojo; Javier Cañada; Asunción Fernández; Soledad Penadés

doi:10.1002/1521-3773(20010618)40:12<2257::AID-ANIE2257>3.0.CO;2-S

Gold Glyconanoparticles as Water-Soluble Polyvalent Models To Study Carbohydrate Interactions

Angew Chem Int Ed Engl. 2001 Jun 18;40(12):2257-2261. doi: 10.1002/1521-3773(20010618)40:12<2257::AID-ANIE2257>3.0.CO;2-S.

Authors

Jesús M de la Fuente¹, Africa G Barrientos¹, Teresa C Rojas², Javier Rojo¹, Javier Cañada³, Asunción Fernández², Soledad Penadés¹

Affiliations

¹ Grupo de Carbohidratos Instituto de Investigaciones Químicas, CSIC Isla de la Cartuja, Américo Vespucio s/n, 41092 Sevilla (Spain) Fax: (+34) 95-448-95-63.
² Instituto de Ciencia de Materiales, CSIC Isla de la Cartuja, Américo Vespucio s/n, 41092 Sevilla (Spain).
³ Instituto de Química Orgánica General, CSIC Juan de la Cierva 3, 28006 Madrid (Spain).

PMID: 29711834
DOI: 10.1002/1521-3773(20010618)40:12<2257::AID-ANIE2257>3.0.CO;2-S

Abstract

Glycosphingolipid clustering and interactions at the cell membrane can be modeled by gold glyconanoparticles prepared with biologically significant oligosaccharides. Such water-soluble gold glyconanoparticles with highly polyvalent carbohydrate displays (see picture, gray hemisphere: gold nanoparticle) have been obtained by a simple and versatile strategy.

Keywords: carbohydrates; glycolipids; gold; nanoparticles; self-assembly.