Format

Send to

Choose Destination
Nature. 1988 Oct 6;335(6190):519-25.

Function of c-mos proto-oncogene product in meiotic maturation in Xenopus oocytes.

Author information

1
Bionetics Research Inc., National Cancer Institute, Frederick, Maryland 21701.

Abstract

The c-mos proto-oncogene is expressed as a maternal mRNA in oocytes and early embryos of Xenopus laevis, but its translation product pp39mos is detectable only during progesterone-induced oocyte maturation. Microinjection of mos-specific antisense oligonucleotides into oocytes not only prevents expression of pp39mos, but also blocks germinal vesicle breakdown, indicating that it functions during reinitiation of meiotic division.

PMID:
2971141
DOI:
10.1038/335519a0
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Nature Publishing Group
Loading ...
Support Center