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Technol Health Care. 2018;26(S1):193-203. doi: 10.3233/THC-174548.

Sparse feature learning for multi-class Parkinson's disease classification.

Author information

College of Computer Science and Software Engineering, Shenzhen University, Key Laboratory of Service Computing and Applications, Guangdong Province Key Laboratory of Popular High Performance Computers, Shenzhen, Guangdong, China.
School of Biomedical Engineering, Health Science Center, Shenzhen University, National-Regional Key Technology Engineering Laboratory for Medical Ultrasound, Guangdong Key Laboratory for Biomedical Measurements and Ultrasound Imaging, Shenzhen, Guangdong, China.


This paper solves the multi-class classification problem for Parkinson's disease (PD) analysis by a sparse discriminative feature selection framework. Specifically, we propose a framework to construct a least square regression model based on the Fisher's linear discriminant analysis (LDA) and locality preserving projection (LPP). This framework utilizes the global and local information to select the most relevant and discriminative features to boost classification performance. Differing in previous methods for binary classification, we perform a multi-class classification for PD diagnosis. Our proposed method is evaluated on the public available Parkinson's progression markers initiative (PPMI) datasets. Extensive experimental results indicate that our proposed method identifies highly suitable regions for further PD analysis and diagnosis and outperforms state-of-the-art methods.


Parkinson’s disease; classification; feature selection; multi-class

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