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Biomed Pharmacother. 2018 Jul;103:889-896. doi: 10.1016/j.biopha.2018.04.117. Epub 2018 Apr 24.

Molecular Landscape in Alveolar Soft Part Sarcoma: Implications for Molecular Targeted Therapy.

Author information

1
Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran; Research Center for Molecular Medicine and Genetics, School of Medicine, Hamedan University of Medical Sciences, Hamedan, Iran.
2
Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran. Electronic address: Taheri@bmsu.ac.ir.
3
Department of Energy and Environmental Biotechnology, Division of Industrial & Environmental Biotechnology, National Institute of Genetic Engineering and Biotechnology (NIGEB), Tehran, Iran.
4
Deputy of Research and Technology, Semnan University of Medical Sciences, Semnan, Iran.
5
Nanobiotechnology Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran.
6
Surgical Oncology Research Center, Imam Reza Hospital, Faculty of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran.

Abstract

Alveolar soft part sarcoma (ASPS) is a highly aggressive rare soft tissue sarcoma (STS) with poor prognosis especially in the metastatic form. ASPS is resistant to standard chemotherapy. Although, early diagnosis and surgical resection of operable tumor could lead to improved patient survival but novel treatment options are needed for advanced (metastatic) ASPS. This malignancy exhibits highly angiogenic behavior which reflects hyper-activation and over expression of angiogenic factors. Understanding the molecular events in this type of sarcoma is important in finding novel molecular based targeted therapies. We aim to review molecular aspects of ASPS growth and treatment.

KEYWORDS:

Alveolar soft part sarcoma; Drug resistance; Molecular targeted therapy; Tyrosine kinase inhibitor

PMID:
29710505
DOI:
10.1016/j.biopha.2018.04.117
[Indexed for MEDLINE]

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