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Eur J Pharmacol. 1988 Jun 10;150(3):393-6.

A highly potent and selective H3 agonist relaxes rabbit middle cerebral artery, in vitro.

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1
Laboratoire de Pharmacologie, UFR de Pharmacie, Limoges, France.

Abstract

An H3-agonist, R alpha methylhistamine strongly relaxed isolated and perfused rabbit middle cerebral artery precontracted with K+. This vasodilatation was not antagonized by either mepyramine or cimetidine but was competitively antagonized by an H3-antagonist, a mixture of impromidine and cimetidine. Histamine activated the H3-sites in this artery since its concentration-response curve (obtained with mepyramine and cimetidine) was parallel to that of R alpha methylhistamine. Our data indicate that H3-sites could exist in the rabbit cerebral artery.

PMID:
2970975
[Indexed for MEDLINE]
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