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Chemotherapy. 1988;34(3):248-55.

High teicoplanin uptake by human neutrophils.

Author information

1
Department of Medicine, Hartford Hospital, Conn.

Abstract

The cellular/extracellular (C/E) concentration ratio of teicoplanin in polymorphonuclear leukocytes (PMNs) increased rapidly with time (C/E 60 +/- 13 at 20 min). The C/E ratio was time- and concentration-dependent. At 20 min and an initial concentration of 75 +/- 16 micrograms/ml the cellular drug concentration was 4,700 +/- 1,300 micrograms/ml. The mechanism of drug uptake was by an active process and transported (cellular) drug retained its antimicrobial activity. Washing removed 42% of cellular drug. Teicoplanin inhibited PMN chemotaxis at very high concentrations and PMN microbicidal activity at lower concentrations.

PMID:
2970950
DOI:
10.1159/000238576
[Indexed for MEDLINE]

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