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Aging Male. 2018 Sep;21(3):158-169. doi: 10.1080/13685538.2018.1468429. Epub 2018 Apr 30.

The impact of testosterone replacement therapy on glycemic control, vascular function, and components of the metabolic syndrome in obese hypogonadal men with type 2 diabetes.

Author information

1
a Department of Endocrinology, Diabetes and Metabolic Diseases , University Medical Center , Ljubljana , Slovenia.
2
b Department of Angiology, Endocrinology and Rheumatology , General Hospital Celje , Celje , Slovenia.
3
c Blaž Antonič s.p., IT Equipment Development , Ljubljana , Slovenia.
4
d Medical Faculty , University of Ljubljana , Ljubljana , Slovenia.

Abstract

OBJECTIVE:

This study set out to assess effects of testosterone replacement therapy (TRT) on parameters of metabolic syndrome and vascular function in obese hypogonadal males with type 2 diabetes mellitus (DM2).

STUDY DESIGN:

Fifty-five obese hypogonadal diabetic males on oral hypoglycemic treatment were enrolled into this one-year, double-blind, randomized, placebo-controlled clinical study. Group T (n = 28) was treated with testosterone undecanoate (1000 mg i.m. every 10 weeks) while group P (n = 27) received placebo.

METHODS:

Anthropometrical and vascular measurements - flow-mediated dilatation (FMD) and intima media thickness (IMT) - biochemical and hormonal blood sample analyses were performed at the start of the study and after one year. Derived parameters (BMI, HOMA-IR, calculated free testosterone (cFT) and bioavailable testosterone (BT)) were calculated.

RESULTS:

TRT resulted in reduction of HOMA-IR by 4.64 ± 4.25 (p < .001), HbA1c by 0.94 ± 0.88% points (p < .001), and an increase in FMD by 2.40 ± 4.16% points (p = .005).

CONCLUSION:

TRT normalized serum testosterone levels, improved glycemic control and endothelial function while exerting no ill effects on the study population.

KEYWORDS:

Diabetes; endothelial function; hypogonadism; insulin resistance; intima media thickness; metabolic syndrome; replacement therapy; testosterone

PMID:
29708829
DOI:
10.1080/13685538.2018.1468429
[Indexed for MEDLINE]

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