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Cell. 2018 May 3;173(4):894-905.e13. doi: 10.1016/j.cell.2018.03.075. Epub 2018 Apr 26.

Dendritic Integration of Sensory Evidence in Perceptual Decision-Making.

Author information

1
Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK.
2
MRC Brain Network Dynamics Unit, University of Oxford, Mansfield Road, Oxford OX1 3TH, UK.
3
Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK. Electronic address: shamik.dasgupta@tifr.res.in.
4
Centre for Neural Circuits and Behaviour, University of Oxford, Tinsley Building, Mansfield Road, Oxford OX1 3SR, UK. Electronic address: gero.miesenboeck@cncb.ox.ac.uk.

Abstract

Perceptual decisions require the accumulation of sensory information to a response criterion. Most accounts of how the brain performs this process of temporal integration have focused on evolving patterns of spiking activity. We report that subthreshold changes in membrane voltage can represent accumulating evidence before a choice. αβ core Kenyon cells (αβc KCs) in the mushroom bodies of fruit flies integrate odor-evoked synaptic inputs to action potential threshold at timescales matching the speed of olfactory discrimination. The forkhead box P transcription factor (FoxP) sets neuronal integration and behavioral decision times by controlling the abundance of the voltage-gated potassium channel Shal (KV4) in αβc KC dendrites. αβc KCs thus tailor, through a particular constellation of biophysical properties, the generic process of synaptic integration to the demands of sequential sampling.

KEYWORDS:

Drosophila melanogaster; decision-making; drift-diffusion model; forkhead box P transcription factors; membrane biophysics; neural integrator; olfaction; potassium channel; synaptic integration

PMID:
29706545
PMCID:
PMC5947940
DOI:
10.1016/j.cell.2018.03.075
[Indexed for MEDLINE]
Free PMC Article

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