Format

Send to

Choose Destination
Int J Hyg Environ Health. 2018 May;221(4):602-608. doi: 10.1016/j.ijheh.2018.04.009. Epub 2018 Apr 23.

Effects of long-term exposure to CO and PM2.5 on microalbuminuria in type 2 diabetes.

Author information

1
National Institute of Environmental Health Science, National Health Research Institutes, 35 Keyan Road, Zhuan, Miaoli County 35053, Taiwan, ROC. Electronic address: weishanlinda@gmail.com.
2
Department of Medical Research, Tung's Taichung Metro Harbor Hospital, No. 699, Sec. 8, Taiwan Blvd., Taichung City, 435, Taiwan, ROC. Electronic address: yogurt8306@gmail.com.
3
Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhuan, Miaoli County 35053, Taiwan, ROC. Electronic address: 030203@nhri.org.tw.
4
Department of Environmental and Occupational Medicine, National Taiwan University (NTU) College of medicine and NTU Hospital, No.1, Changde St., Zhongzheng Dist., Taipei City 10048, Taiwan, ROC. Electronic address: tracyperf@gmail.com.
5
Institute of Population Health Sciences, National Health Research Institutes, 35 Keyan Road, Zhuan, Miaoli County 35053, Taiwan, ROC; Department of Health Services Administration, China Medical University, No. 91, Hsueh-Shih Road, Taichung, Taiwan 40402, Taiwan, ROC; Department of Family Medicine, Min-Sheng General Hospital, No.168, ChingKuo Rd, 330 Taoyuan, Taiwan, ROC. Electronic address: cch@nhri.org.tw.
6
National Institute of Environmental Health Science, National Health Research Institutes, 35 Keyan Road, Zhuan, Miaoli County 35053, Taiwan, ROC; Department of Environmental and Occupational Medicine, National Taiwan University (NTU) College of medicine and NTU Hospital, No.1, Changde St., Zhongzheng Dist., Taipei City 10048, Taiwan, ROC. Electronic address: leonguo@ntu.edu.tw.

Abstract

OBJECTIVE:

No study has examined the effects of air pollutants on albuminuria in type 2 diabetes. Therefore, the present study investigated this association.

METHODS:

This follow-up study enrolled 812 patients with type 2 diabetes between 2003 and 2012. The urinary albumin-to-creatinine ratio (ACR) was recorded annually. Exposure to the air pollutants CO, NO2, O3, SO2, and PM2.5 was interpolated from 72 air-quality monitoring stations to residences by using the kriging method. The association between air pollutants and ACR increase was assessed using mixed-effect model with random intercepts for 36 clinics.

RESULTS:

The study objects (mean age: 55.4 years) were followed for 3 or more years (average period: 5.4 years). ACR increase was found to be positively associated with the male sex, baseline hemoglobin A1c, and exposure to CO and PM2.5, and negatively associated with waist circumference through multiple linear regression. Annually urine albumin/creatinine ratio increase was estimated by the final model, Patients exposed to higher levels of CO (e.g., third quartile, 1025 ppb) and lower levels of CO (e.g., first quartile, 850 ppb) had an annual ACR increase of 3.73 and 3.54 mg/g, respectively. Patients exposed to higher levels of PM2.5 (e.g., third quartile, 38.8 μg/M3) and lower levels of PM2.5 (e.g., first quartile, 27.7 μg/M3) had an annual ACR increase of 3.96 and 3.17 mg/g, respectively.

CONCLUSIONS:

Exposure to high CO and PM2.5 levels increased albuminuria in type 2 diabetes.

KEYWORDS:

Air pollution; CO; Diabetic nephropathy; PM(2.5)microalbuminuria; Type 2 diabetes (T2DM)

PMID:
29706436
DOI:
10.1016/j.ijheh.2018.04.009
[Indexed for MEDLINE]

Supplemental Content

Full text links

Icon for Elsevier Science
Loading ...
Support Center