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Proc Natl Acad Sci U S A. 1988 Aug;85(16):6202-6.

Reexpression of a developmentally regulated antigen in Down syndrome and Alzheimer disease.

Author information

1
Department of Pathology, Albert Einstein College of Medicine, Bronx, NY 10461.

Abstract

ALZ-50 is a monoclonal antibody that recognizes a protein of apparent molecular mass 68 kilodaltons (A68). The protein is present in the brains of patients with Alzheimer disease but is not detectable in normal adult brain tissue. We now report that ALZ-50-reactive neurons are found in normal fetal and neonatal human brain and in brain tissue from neonatal individuals with Down syndrome. Reactive neurons decrease sharply in number after age 2 and reappear in older individuals with Down syndrome and in patients with Alzheimer disease.

PMID:
2970636
PMCID:
PMC281933
[Indexed for MEDLINE]
Free PMC Article

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